Efficacy of Simvastatin in the treatment of nonalcoholic fatty liver disease and observation on changes of blood lipid

Objective To explore the efficacy of different doses of Simvastatin in the treatment of nonalcoholic fatty liver disease(NAFLD) and its relationship with changes of blood lipid level.Methods 120 patients with NAFLD were randomly divided into high dose group(Simvastatin 40 mg/d),small dose group(Simvastatin 10 mg/d) and control group,each group had 40 cases.Blood lipid,liver function and liver B-mode ultrasonography were detected before treatment and 6 months after treatment,and the serum lipid changes and the curative effect were analyzed.Results Before treatment,the total cholesterol(TC),triglyceride(TG) were not significantly different among three groups(P 0.05).After treatment,the TC,TG [high dose group:(3.27±0.65),(2.45±0.63) mmol/L;small dose group:(4.42±0.87),(3.32±0.72) mmol/L;control group:(5.60±0.93),(3.51±1.36) mmol/L] were significantly lower than before [high dose group:(6.78±1.13),(4.90±1.77) mmol/L;small dose group:(6.49±1.06),(4.88±1.64) mmol/L;control group(6.83±1.24),(4.93±1.80) mmol/L],the differences were significant(all P 0.05).Except for TG had no statistical difference between the small dose group and the control group after treatment(P 0.05),the TC,TG levels were significant different among three groups(all P 0.05),and the levels ordinal increased in high dose group,small dose group and control group.The effective power in high dose group,low dose group and control group was 90.00%(36/40),82.50%(33/40) and 60.00%(24/40) respectively,which had no significant difference between high dose group and small dose group(P 0.05),but those in the two groups were higher than those in the control group(all P 0.05).Conclusion Simvastatin can decrease the blood lipid levels,improve liver function,and relieve the clinical symptoms of NSFLD effectively.But there is no further improved efficacy by increasing dose of Simvastatin.