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Preparation Technology and Characterization of Naproxen Microspheres

Jin Wang

Open publisher page 1 citations

Abstract

A complex coacervation method was used to prepare Naproxen microspheres using chitosan and Gum-arabic as the matrix materials.The orthogonal experimental design using the standard of drug encapsulation was applied to optimize the preparation procedure of the microspheres.The result showed that optimal technology were C(chitosan:alginate)=1:1,pH=4.0,r=300 rpm,T=35 ℃.The release in vitro of the microspheres indicated that these microspheres may prove better sustained release of drugs.

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What this paper is about

A complex coacervation method was used to prepare Naproxen microspheres using chitosan and Gum-arabic as the matrix materials.The orthogonal experimental design using the standard of drug encapsulation was applied to optimize the preparation procedure of the microspheres.The result showed that optimal technology were C(chitosan:alginate)=1:1,pH=4.0,r=300 rpm,T=35 ℃.The release in vitro of the microspheres indicated that these microspheres may prove better sustained release of drugs.

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Available abstract

A complex coacervation method was used to prepare Naproxen microspheres using chitosan and Gum-arabic as the matrix materials.The orthogonal experimental design using the standard of drug encapsulation was applied to optimize the preparation procedure of the microspheres.The result showed that optimal technology were C(chitosan:alginate)=1:1,pH=4.0,r=300 rpm,T=35 ℃.The release in vitro of the microspheres indicated that these microspheres may prove better sustained release of drugs.

Key concepts: Coacervate, Microsphere, Naproxen, Chitosan, Chemistry, Gum arabic, Matrix (chemical analysis), Chromatography

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