The preparation technique and characterization of nimodipine-chitosan microspheres

Purpose To study the method which was used to prepare nimodipine microspheres with chitosan-Gum-arabic by means of a complex coacervation method in an emulsion system.Methods The orthogonal experimental design using the standard of drug encapsulation was applied to optimize the preparation procedure of the microspheres.Results The optimal preparation technique was as follows:400 r/min,pH 4.5,chitosan∶Gum-arabic=1∶1,and amount of glutaraldehyde is 1%.Conclusion This method was reproducible.The release of the microspheres in vitro indicated that these microspheres may prove better sustained release of drugs.