Experimental study on mice with immune-mediated aplastic anemia

An aplastic anemia model was established in mice. When BALB/c mice were given 1 × 106/0.2 ml lymph node and thymus cells obtained from DBA/2 mice immediately after 5 Gy wholebody irradiation, the aplastic anemia incidence was 96.67 %, developed duration focused in 10 - 24 days, repeat experiment were basically identical and animal death time was longer. The decrease of blood count and marrow nuclear cells, change in T lymphocyte subsets, IFN-γ and pathological examination were consistent with those of aplastic anemia in human being. Therefore, this animal model might provide an useful means for studies on the pathogenesis and treatment of aplastic anemia.