Oxidative Stress Damage Induced by Irradiation in Mouse Kidney and the Protective Effect of Ligustrazine against it

Objective: To investigate the oxidative stress damage induced by irradiation in mouse kidney and the preventive and therapeutic effect of Ligustrazine against it.Methods: Mice were exposed to 5Gy single 60Co-irradiation to induce oxidative stress,the concentration of Ligustrazine for intraperitoneal is 130 mg/kg to prevent and treat liver injury before and after irradiation,The injection lasted 10 days.The parameters of malondialdehyde(MDA),superoxide dismutase enzyme(SOD),catalase(CAT),reduced glutathione hormone(GSH),glutathione peroxidase(GPx),total antioxidation capability(T-AOC)activity in kidney were measured.Results: Com-pared with that in the normal control group,irradiation significantly increased kidney content of MDA(P0.05),decreased CAT,SOD activity(P0.05),GSH-Px activity(P0.05),while it decreased kidney content of GSH(P0.05),the kidney tissue T-AOC decreased(P0.05).By use of Ligustrazine,MDA content decreased(P0.05),T-AOC were significantly higher(P0.05),CAT activity increased(P0.05) and the effect of treatment group was better than the prevention group had no significant difference(P0.05) compared with that in the normal group.Meanwhile,the activity of SOD and the content of GSH significant increased in prevention group(P0.05);The ac-tivity of SOD and CAT significant increased in treatment group(P0.05);But GSH-Px activity was no significant difference either in treatment group or in prevention group.Conclusion: The irradiation can cause oxidative stress damage in mouse kidney tissue,Ligus-trazine can reduce or reverse this damage both in treatment and prophylaxis,and treatment group is better than the prevention group.