Protective effects of ligustrazine against oxidative stress induced by irradiation in mice

OBJECTIVE:To study the preventive and therapeutic effect of ligustrazine against irradiation-induced oxidative stress.METHODS:Mice were exposed to 5 Gy single Co- 7 irradiation to induce oxidative stress,the concentration of ligustrazine for daily intraperitoneal injection was 31.2 mg/kg to prevent and treat liver injury before and after irradiation.The injection lasted 10 days.We measured the parameters of malondialdehyde(MDA),superoxide dismutase enzyme(SOD),catalase(CAT),reduced glutathione(GSH),glutathione peroxidase(GPx),total antioxidation capability(T- AOC) activity in liver.RESULTS:Compared with negative control group,MDA was increased(P0.05),the activities of SOD,GSH,GPx and T-AOC were decreased in the liver(P0.05) after irradiation,while the activity of CAT was not changed significandy(P0.05).By using ligustrazine,compared with irradiation group,MDA was decreased(P0.05) and the activities of GSH,SOD,GPx,and T-AOC were increased significantly(P0.05),whereas the activity of CAT was not changed significandy(P0.05).CONCLUSION:Ligustrazine could reduce the oxidative injury induced by irradiation, either as prevention or treatment.