The Change Of Large Arterial Compliance In Prehypertensive People

ObjectiveTo investigate the changes of compliance in large arteries in prehypertensive people.Methods 191 subjects with no obvious target organ damage were allocated into 3 groups, normotensive(n=64), prehypertensive (n=25) and hypertensive patients(n=52).Age, SBP, DBP, PP, HR, height, BMI, and waist/hip ratio were measured.ResultsThe mean C-FPWV and C-RPWV in prehypertensives group(9.7±1.5 and 9.7±1.4)m/s was greater than that of normotensives[(8.9±1.6 and 8.8±1.1) m/s, P0.05] and less than that of hypertensives[(10.0±1.4 and 10.3±1.8)m/s, P0.05].One way ANOVA showed that all above variables but age and HR were significantly different among the 3 groups.Weight, height, BMI waist/hip ratio, C-RPWV, and C-FPWV in prehypertensive groups were greater than that of normotensive (all P0.05). C-RPWV was correlated with SBP, DBP, height, and HR, while C-FPWV with age, SBP, PP and BMI.Multiple regression analysis showed that age, SBP, height, and weight were the main determinants for C-FPWV, while DBP and HR were closely related to C-RPWV.ConclusionPrehypertensive patients already had change of compliance in large arteries even no obvious target organ damage was found. Arterial compliance was decreased with the increase of age, blood pressure, heart rate in prehypertensive patients.