Imipenem resistance among Pseudomonas aeruginosa isolates:antimicrobial susceptibility analysis and epidemiology in Guangzhou area

Objective To investigate the infection status and antimicrobial susceptibility of imipenem -resistant Pseudomonas aeruginosa to instruct clinical application of antibiotics.Methods Imipenem -resistant Pseudomonas aeruginosa strains isolated from Guangdong Provincial Hospital of Traditional Chinese Medicine,the first Affiliated Hospital of Guangzhou University of Chinese Medicine, Southern Hospital and the Second Affiliated Hospital of Sen Yat-sen University from 2005 to 2007 were collected and identified by VITEK-32 system.The minimal inhibitory concentrations(MIC) of them to 9 antibiotics,including imipenem,meropenem,cefotaxime,cefepime,gentamycin,amikacin, aztreonam,ciprofloxacin,and levofloxacin were detected by applying agar dilution method.Results A total of 440 strains of imipenem-resistant Pseudomonas aeruginosa were obtained from 4 major hospitals in Guangzhou province,in which 81 isolates were resistant to imipenem(18.41%).There was significant difference of drug resistance rate between imipenem resistance group and imipenem non-resistance group,especially to gentamicin(65.43%vs 10.86%),ceftazidime(53.09%vs 10.03%) and amikacin(53.09%vs 12.26%).Conclusion Imipenem resistant Pseudomonas aeruginosas are resistant to many kinds of antimicrobial agents,and their resistant rate is increased year by year,in order to control and slow down the occurrence of the persisters,it should be paid more attention to choose antimicrobial agents rationally according to antimicrobial susceptibility test results and individual conditions of patients.