Distribution and antibiotics resistance analysis of hospital acquired imipenem-resistant Pseudomonas aeruginosa isolates

Objective:To providing a basis of hospital infection prevention and rational use of antibiotics,the section distribution,sources and antibiotics resistance of imipenem-resistant Pseudomonas aeruginos were analyzed in Harbin area.Methods:Clinical samples were collected and K-B disc diffusion method was used for drug susceptibility tests.Results:Sputums and wound secretions were the main clinical sources of the Imipenem-resistant Pseudomonas aeruginosas.The best susceptibility was amikacin of 62%,aztreonam,piperacillin/tazobactam,cefoperazone/sulbactam of 58%,57%,52% respectively;gentamicin,piperacillin,ceftazidime,levofloxacin,showed lower susceptibility of 26%,34%,38% and 40%,respectively.While amoxicillin/clavulanic acid presented the highest resistance of 90%,panipenem,cefotaxime and gentamicin of 76%,74%,69%,respectively.Conclusions:Imipenem-resistant Pseudomonas aeruginosas usually represent multi-drug resistance,as the result strengthen prevention and rational use of antibiotics should be taken to prevent the infection and reduce drug resistance of Pseudomonas aeruginosas isolates.