Clinical study of Parkinson disease treated with Bushen Huoxue Decoction

Objective To observe the clinical efficacy of Bushen Huoxue Decoction on Parkinson disease. Methods 70 cases of Parkinson disease were randomly divided into treatment group(35 cases) and control group(35 cases). All the cases came from the out-patients and in-patients of the Second Affiliated Hospital of Xi'an Jiaotong University from September 2006 to September 2012. In treatment group, Bushen Huoxue Decoction and madopar were administered. In control group, madopar was only administered. The duration of treatment was 3 months. The unified Parkinson disease rating scale(UPDRS) was used to score the symptoms and physical signs before and after medication in two groups.The incidence of non-motor symptoms of two groups was observed, including insomnia, profuse sweating, mental disturbance, fatigue, unknown pain, cognitive dysfunction, etc.. Results Before and after treatment, UPDRS scores were much more different in treatment group when compared with control group, indicating a statistically significant difference(P 0.05). After medication, in treatment group, of non- motor symptoms, the incidences of insomnia, defecation dysfunction, profuse sweating and fatigue were significantly different in statistics when compared with control group(P 0.05);and those of mental disturbance, unknown pain and cognitive dysfunction decreased as compared with control group,but there was no significant difference(P 0.05). Conclusion Bushen Huoxue Decoction can improve apparently not only in the motor symptoms of the patients with Parkinson disease but also in many non-motor symptoms patient such as insomnia, defecation dysfunction, profuse sweating and fatigue.