EXPRESSION AND CLINICAL SIGNIFICANCE OF POKEMON AND C-MYC IN COLORECTAL CANCER
Liu Shu-mi
Abstract
Liu Shu-mi
Abstract
Objective: To investigate the expression and clinical significance of Pokemon and c-myc in human colorectal cancer. Methods: SP immunohistochemical staining was used to detect the expression of Pokemon and c-myc in 60 cases colorectal cancer and matched para-carcinoma tissues. Results:The positive expression rate of Pokemon and c-myc in colorectal cancer were obviously higher than that in normal tissue(P 0.01). In colorectal cancer, the positive expression of Pokemon and c-myc were related with differentiation degree, Dukes stage and lymph node metastasis(P0.01, P0.05). The positive expression of Pokemon in colorectal cancer was positively correlated with c-myc expression(r=0.615, P0.05). Conclusions: Pokemon and c-myc have certain value for diagnosing and prognosis of colorectal cancer.
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Objective: To investigate the expression and clinical significance of Pokemon and c-myc in human colorectal cancer. Methods: SP immunohistochemical staining was used to detect the expression of Pokemon and c-myc in 60 cases colorectal cancer and matched para-carcinoma tissues. Results:The positive expression rate of Pokemon and c-myc in colorectal cancer were obviously higher than that in normal tissue(P 0.01). In colorectal cancer, the positive expression of Pokemon and c-myc were related with differentiation degree, Dukes stage and lymph node metastasis(P0.01, P0.05). The positive expression of Pokemon in colorectal cancer was positively correlated with c-myc expression(r=0.615, P0.05). Conclusions: Pokemon and c-myc have certain value for diagnosing and prognosis of colorectal cancer.
Key concepts: Colorectal cancer, Immunohistochemistry, Lymph node metastasis, Medicine, Clinical significance, Cancer, Cancer research, Oncology