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2005•Acta Academiae Medicinae WannanRequires access

FOLFOX4 regimen in the treatment of advanced colorectal cancer: A report of 23 cases

Zhimin Yang

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Abstract

Objective To evaluate the effects and toxicities of FOLFOX4 regimen for treating patients with advanced colorectal cancer. Methods OXA 85 mg/m+2 was given intravenously 2 h,d1, CF 200 mg/m+2 iv 2 h followed by 5-Fu 400 mg/m+2 iv bolus plus 5-Fu 600 mg/m+2 iv continuous infusion 22 hours d1～2. Each cycle was in divided doses for a period up to 14 days. Results The overall response rate (CR+PR) was 47.83%, and a median time to progression was 8.3 months. The side effects were commonly seen with mild neuro-sensory toxicity, mucitis suppression of bone marrow, diarrhea, nausea and vomiting of grade I to II. Conclusion FOLFOX4 regimen is highly effective and well tolerated in treatment of advanced colorectal cancer.

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What this paper is about

Objective To evaluate the effects and toxicities of FOLFOX4 regimen for treating patients with advanced colorectal cancer. Methods OXA 85 mg/m+2 was given intravenously 2 h,d1, CF 200 mg/m+2 iv 2 h followed by 5-Fu 400 mg/m+2 iv bolus plus 5-Fu 600 mg/m+2 iv continuous infusion 22 hours d1～2. Each cycle was in divided doses for a period up to 14 days. Results The overall response rate (CR+PR) was 47.83%, and a median time to progression was 8.3 months. The side effects were commonly seen with mild neuro-sensory toxicity, mucitis suppression of bone marrow, diarrhea, nausea and vomiting of grade I to II. Conclusion FOLFOX4 regimen is highly effective and well tolerated in treatment of advanced colorectal cancer.

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Available abstract

Objective To evaluate the effects and toxicities of FOLFOX4 regimen for treating patients with advanced colorectal cancer. Methods OXA 85 mg/m+2 was given intravenously 2 h,d1, CF 200 mg/m+2 iv 2 h followed by 5-Fu 400 mg/m+2 iv bolus plus 5-Fu 600 mg/m+2 iv continuous infusion 22 hours d1～2. Each cycle was in divided doses for a period up to 14 days. Results The overall response rate (CR+PR) was 47.83%, and a median time to progression was 8.3 months. The side effects were commonly seen with mild neuro-sensory toxicity, mucitis suppression of bone marrow, diarrhea, nausea and vomiting of grade I to II. Conclusion FOLFOX4 regimen is highly effective and well tolerated in treatment of advanced colorectal cancer.

Key concepts: Medicine, Regimen, Nausea, Bolus (digestion), Colorectal cancer, Vomiting, Gastroenterology, Bone marrow suppression

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FOLFOX4 regimen in the treatment of advanced colorectal cancer: A report of 23 cases — Research Paper | ScholarLens