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The influence of varied doses and time of cisplatin on the growth of COC1and COC1/DDP cells

Zeng Yu-hua

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Abstract

Objective:To study the of ovarian mechanism cancer multidrug-resistant in vitro and to dependence provide the of clinic choosing predicting therapy,prognosis finding and effective resistance reverse drug methods.Methods:Flow cytometry used to apoptosis observe the was of COC1 and COC1/DDP cells.Results:DDP could the of COC1 and inhibit COC1/DDP growth cells in a dose-dependent fashion.As compared that to of COC1 apoptosis cells,the of cells COC1/DDP was apparently inhibited with by DDP concentration the ranges of 2.5-10μg/mL (P0.05).Conclusion:As compared to that of COC1 cells,apoptosis the of COC1/DDP apparently cells inhibited was by DDP.DDP could induce the apoptosis of COC1 and COC1/DDP cells.drug resistance apoptosis Acquired is related to.

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Objective:To study the of ovarian mechanism cancer multidrug-resistant in vitro and to dependence provide the of clinic choosing predicting therapy,prognosis finding and effective resistance reverse drug methods.Methods:Flow cytometry used to apoptosis observe the was of COC1 and COC1/DDP cells.Results:DDP could the of COC1 and inhibit COC1/DDP growth cells in a dose-dependent fashion.As compared that to of COC1 apoptosis cells,the of cells COC1/DDP was apparently inhibited with by DDP concentration the ranges of 2.5-10μg/mL (P0.05).Conclusion:As compared to that of COC1 cells,apoptosis the of COC1/DDP apparently cells inhibited was by DDP.DDP could induce the apoptosis of COC1 and COC1/DDP cells.drug resistance apoptosis Acquired is related to.

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Available abstract

Objective:To study the of ovarian mechanism cancer multidrug-resistant in vitro and to dependence provide the of clinic choosing predicting therapy,prognosis finding and effective resistance reverse drug methods.Methods:Flow cytometry used to apoptosis observe the was of COC1 and COC1/DDP cells.Results:DDP could the of COC1 and inhibit COC1/DDP growth cells in a dose-dependent fashion.As compared that to of COC1 apoptosis cells,the of cells COC1/DDP was apparently inhibited with by DDP concentration the ranges of 2.5-10μg/mL (P0.05).Conclusion:As compared to that of COC1 cells,apoptosis the of COC1/DDP apparently cells inhibited was by DDP.DDP could induce the apoptosis of COC1 and COC1/DDP cells.drug resistance apoptosis Acquired is related to.

Key concepts: Apoptosis, Flow cytometry, Cisplatin, Cytometry, In vitro, Medicine, Chemistry, Chemotherapy

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The influence of varied doses and time of cisplatin on the growth of COC1and COC1/DDP cells — Research Paper | ScholarLens