Clinical observation on the effect of perindopril combined with trimetazidine on senile patients with heart failure

Objective To study the effects of perindopril combined with trimetazidine on chronic heart failure(CHF) in senile people.Methods Seventy-two senile CHF patients were randomly divided into two groups:the treatment group that were given perindorpril 4mg/d and trimetazidine 20mg tid and the control group that were give trimetazidine and balm.Both were treated for 3 months and based on the same fundamental drugs.Blood pressure(BP),stroke volume(SV),cardiac index(CI),left ventricular ejection fraction(LVEF),and side effects were recorded in both groups.Results After 3 months' treatment,the clinical effect rate in cardiac function in the treatment group was higher than that in the control(93.8% vs 63.9%,P0.05),and the improvement in BP,SV,and CI were more obvious in the treatment groups.Conclusion Perindopril combined with trimetazidine has more effects on CHF than acting alone.