Combination of Trimetazidine and Perindopril for Chronic Congestive Heart Failure:Effect Observation of 90 Cases

Objective To observe the curative effect of perindopril combined with trimetazidine(TMZ)to treat chroniccongestive heart failure(CHF).Methods Ninety patients with CHF were randomly divided into experimental group and control group.All patients were given con-ventional medical treatment.Perindopril was added to the control group,the initial dose of 2mg/d,gradually increased to target dose of 4mg/d;Besides Perindopril,trimetazidine was added to the experimental group,20mg,tid,.3 month later,the curative effect was evaluated.Results The cardiac function in two groups were significant improved.The clinical total effective rate was 95.6% in the experimental group,higher than that in the control group(80.0%),and the blood pressure was significantly improved in the two groups(P0.05).After treatment,LVEF,LESV and LEDV were significant improved than before(P0.05),with much more improvement in the treatment group(P0.05).Side effects were both not found in the two groups.Conclusion Combination of trimetazidine and perindopril for CHF is safe,more effective than perindopril used alone.