Analysis and study on syndrome and formula of hyperthyroidism treated by traditional Chinese medicine

Objective:To explore the TCM syndrome differentiation and treatment laws and diagnosis-treatment system of theory,therapies,formulae and medicine on hyperthyroidism.Methods:Frequency analysis and classified analysis were used with SPSS 18.0 for the literature in treating hyperthyroidism by TCM collected in CNKI from January 1979 to June 2012,to summarize the TCM syndromes and main symptoms,and to analysis syndrome elements and disease location at Zang and Fu,for obtaining the characteristics of TCM syndrome,therapy and formula of hyperthyroidism.Results:Total of 44 syndromes were counted in 160 articles,among them,syndrome of deficiency of both qi and yin,mutual stagnation of phlegm and qi,stagnation of liver qi,excess of liver fire,accumulation of phlegm and blood stasis,yin-deficiency and fire-excess were the main syndromes of hyperthyroidism;5 classified syndromes were achieved through hierarchical cluster analysis to the counted symptoms,they were syndrome of deficiency of qi and yin,yin-deficiency and fire-excess,syndrome of stagnation of liver and fire-excess,qi and yin deficiency,syndrome of deficiency of qi and blood,accumulation of phlegm an blood stasis with dampness and heat,syndrome of yin-deficiency of liver and kidney,stagnation of phlegm and qi,phlegm and dampness blocking meridians,syndrome of yindeficiency and fire-excess,accumulation of phlegm and dampness.And the clustering syndromes were basically the same as the main syndromes achieved by frequency analysis.Excess pathogenesis occupied the majority(the rate was 59.10%) in all syndrome pathogenesis,mainly were fire and heat,stagnation of qi,coagulation of phlegm,deficiency pathogenesis occupied 40.90%,mainly were yin-deficiency and qi-deficiency;disease location mainly in liver,kidney,heart,spleen and stomach.311 formulae were attained,composition formulae could be classified into 14 types according formula textbooks,the main types concluded tonify formula,heat-clearing formula,mediation formula,phlegm-removing formula,regulating qi formula,tranquilizer formula;experimental formulae mainly were composed in terms of therapies of clearing heat and fire,removing phlegm and dispersing coagulation,regulating liver and relieving stagnation,nourishing yin and blood.282 kinds of Chinese medicine were involved in,could be classified into 19 types,among which,Chinese medicine of heat-clearing,tonifying deficiency,removing phlegm,relieving cough and asthma,activating blood regulation and removing stasis,stabilizing live and removing wind were the most used,occupied 75.60%,and application of clearing heat medicine located the first,Xiakucao(prunella vulgaris) was used the most in it.Classified meridians of Chinese medicine of treating hyperthyroidism mainly were liver,lung,heart,kidney,spleen and stomach,which were matched up with the disease location.7 clustering formulae were achieved through hierarchical cluster analysis methods to 67 counted Chinese medicines,which were applied the following types of hyperthyroidism:syndrome of qi stagnation and blood stasis,yin-deficiency and fire-excess of heart,liver and kidney,yin-deficiency and yang-excess,accumulation of blood stasis and heat,qi stagnation and phlegm coagulation.Conclusion:Clinical research on analyzing etiology and pathogenesis,syndrome differentiation and treatment,formula composition and Chinese medicine application of hyperthyroidism form TCM can provide reference for the diagnosis,syndrome differentiation and treatment of this disease.