Combined detection of infection markers in early diagnosis of neonatal sepsis

Objective:To investigate the application value of leukocyte surface antigens CD64,serum procalcitonin(PCT)and hs-CRP in the early diagnosis of neonatal sepsis.Methods:A total of 200 patients were divided into sepsis group(n=100)and non-infection group(n=100),and the leukocyte surface antigens CD64,PCT and hs-CRP were measured before the use of antibiotics.The three markers were measured again 7days after treatment for 50sepsis patients in effective remedy as recovery group. The CD64,PCT and hs-CRP were detected by FCM,ECLIA and nephelometry,respectively.Results: The levels of CD64,PCT and hs-CRP in the sepsis group were higher than those in non-infection group(P0.05),and were decreased significantly in the recovery group compared with the sepsis group(P 0.05).Compared with any single measurement,the sensitivity,specificity,positive predict value(PPV), negative predict value(NPV)and Youden index of combined detection were apparently increased.Conclusion:The combined detection of CD64,PCT and hs-CRP may be useful for the early diagnosis and curative effect evaluation of neonatal sepsis.