Clinical study of CD64 combined with C-reactive protein and procalcitonin in the detection of neonatal sepsis

Objective To investigate the significance of CD64 combined with C-reactive protein(CRP) and procalcitonin(PCT) in the diagnosis of neonatal sepsis. Methods A total of 70 neonates diagnosed with neonatal sepsis(sepsis group), 35 cases of non-infectious diseases(non-infected group), and 40 healthy newborns(healthy control group) were enrolled in the Department of Pediatrics, Fuzhou First Hospital Affiliated to Fujian Medical University from July 2015 to June 2016.Serum CD64 was detected by flow cytometry.Serum CRP and PCT were detected by automatic biochemical analyzer, and the results were compared and analyzed. Results The levels of serum CD64, CRP and PCT in sepsis group were significantly higher than those in non-infected group and healthy controls(P<0.05). The sensitivity and specificity of CD64 combined with CRP and PCT in the detection of neonatal sepsis were 97.14% and 96.00%, and the sensitivity and specificity in the combined detection were higher than those in three indicators alone. Conclusion CD64 combined with CRP and PCT in the detection of neonatal sepsis can improve the specificity, and provide the basis for early diagnosis. Key words: CD64; C-reactive protein; Procalcitonin; Sepsis