STUDIES ON GENOTOXICITY OF NON-VOLATILE ORGANIC CHEMICALS IN HUAI RIVER WATER

Purpose: To study the genotoxicity of non-volatile organic chemicals in Huai river water to organism. Methods: zool of water sample was collecfed from Huai river source water、clarified filtration water、chlorinated tap water and reservoir's water, respectively. After being adsorpted and concentrated, water samples were administrated by gavage into mouse stomach. The mutagenicity was studied by means of micronucleus test in mouse thoracic bone-marrow polychromatic erythrocyte (PCE) and the genotoxicity by means of sperm morphologic analysis. Results: the mutagenicity and sperm deformity of some degree are induced by Huai river source water and tap water. The order of mutagenic potentiality of those samples is as follows: chlouinated tap water reservoir's water source water clarifying fillration water. Conclusion: The source water is contaminated by organic mutagens. Using coagulation and precipitation, genotoxicity of source water is decreased because of the removal of some mutagenic organic chemicals. Addifionally chlorination can increase the genotoxicity of tap water.