2011•Zhongguo shiyan fangjixue zazhiRequires access

Protective Effect of Total Salvianolic Acids on Myocardium Injury Induced by Ischemia-reperfusion in Isolated Rat Heart

Cui Hanming

Abstract

Objective:To observe the direct protective effect of total salvianolic acids(TSA) on myocardium injury induced by ischemia-reperfusion in isolated rat heart.Method: Heart ischemia-reperfusion model was induced in the isolated rat heart subjected to 31 min ischemia and 30 min reperfusion at constant pressure.The left ventricular pressure(LVP),coronary flow(CF) were recorded and the influences of different doses of TSA in KH solution on the changes of heart function parameter were observed.Result: TSA treated hearts showed significant recovery of post-ischemic contractile function(The levels of LVDP,± dp /dtmax,CF and LVEDP(P 0.05-0.01).Conclusion:TSA has direct protective effect on myocardium injury induced by ischemia-reperfusion.

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Key concepts: Preload, Ischemia, Reperfusion injury, Myocardial ischemia, Ventricular pressure, Cardiology, Medicine, Internal medicine