2001•Zhongguo sheng-hua yaowu zazhiRequires access
The hemostatic and protective effect of human fibrin sealant on liver trauma in rats
Xia Shao
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Abstract
PurposeThe aim is to investigate the hemostatic and protective effect of fibrin sealant(FS) on liver trauma in rats.MethodsOn the surface of cracked wound(type Ⅰ) and resected wound(type Ⅱ),spraying of FS or thrombin or direct suturation, was used receptively. Natural hemostasis was used as control.During postoperation the hemostatic time and the state of wound healing on 1st, 4th, 7th,14th, 50th day were observed.ResultsCompared with the natural hemostasis,the hemostatical time of the FS group was shorter 86.0%( P0.01 )in liver trauma type Ⅰ and 79.0%( P0.01 )in liver trauma type Ⅱ.Compared with the thrombin group,the hemostatical time of the FS group was shorten 45.0%( P0.01 )in liver trauma type Ⅰ and 84.0%( P0.05 ) in liver trauma type Ⅱ.The wound surface of FS group was healed faster than that of other groups.ConclusionFS was an effective hemostatic and healing promoter on liver trauma of rats.