Application of lidocaine plus etomidate for elderly painless gastroscopy

Objective To explore the efficacy and safety of lidocaine combined with etomidate for the elderly painless gastroscopy. Methods Total of 150 patients undergoing painless gastroscopy were randomly and equally allocated into 3 groups(n=50): LE group(lidocaine combined with etomidate), FE group(fentanyl combined with etomidate) and FP group(fentanyl combined with propofol). Gastroscopy was performed after the eyelash reflex disappearing. MAP, RR, HR and SpO2 were monitored and recorded at the time point of before medication(T0), examination start(T1), gastroscopy go through glottis(T2), end of the operation(T3) and the time of recovery(T4). Recovery time, the anesthesia induction time, gastroscopy time and complications issue were also recorded. Results In group LE and group FE, the MAP, t HR and RR at T1 and the RR at T2 were increased significantly compared with in group FP(P0.05). In group LE and group FE, the hypotension, apnea, injection pain and the use rate of ephedrine were decreased significantly compared with in group FP(P0.05). Compared with group FE, the incidence of myoclonus, nausea and vomiting in group LE and group FP, somnolence in group LE and dizziness in group FP were decreased significantly(P0.05). Conclusion Lidocaine plus etomidate is effective and less adverse reaction for elderly painless gastroscopy.