p21 and TNF-α gene polymorphisms and susceptibility of Xinjiang Kazakh esophageal family

OBJECTIVE:To investigate the correlation of polymorphisms of p21and TNF-αand their combined role in the risk of susceptibility to esophageal cancer in Kazak in Xinjiang.METHODS:SNPs in the 3′UTR of p21and TNF-α308were genotyped by the PCR-RFLP in 43Kazakh esophageal family and 40Non-esophageal family.RESULTS: The genotype frequencies of 3′UTR of p21in the in Kazakh esophageal family were significantly different from that in control group(P=0.033,OR=2.502,95%CI:1.153-6.987).Different genotypes frequencies of p21in esophageal cancer patients and non-esophageal cancer patients were significantly different,TT and TC genotypes can significantly increase the risk of esophageal cancer(P=0.004,OR=11.243,95%CI:1.393-16.743).The genotype frequencies of TNF-α308 in the in Kazakh esophageal family differed from those in the control group(P=0.004,OR=8.786,95%CI:2.824-12.322).Different genotype frequencies of TNF-α308in esophageal cancer patients and non-Esophageal cancer patients were significantly different(P=0.031,OR=2.821,95%CI:1.722-5.016).When the two genotype polymorphisms were combined to analyze,individuals with the TNF-α308GA+AA and p21TC+CC genotypes were played some role in the family aggregation of XinJiang Kazakh esophageal carcinoma(P=0.023);the two genotype polymorphisms in esophageal cancer patients and non-Esophageal cancer patients were not significantly different(P0.05).CONCLUSION:The polymorphism of p21 3′UTR and TNF-α308is likely to be related with the susceptibility to esophageal cancer of Xinjiang Kazakh esophageal family.