Study of CTPIA1,GSTT1,GSTM1 polymorphisms and susceptibility on esophageal carcinoma in Ningxia Hui nationality

Objective To investigate the relationship between CYP1A1,GSTT1,GSTM1 gene polymorphism and esophageal cancer susceptibility in Ningxia Hui nationality.Methods 40 samples form patients with esophageal cancer and 80 healthy control were collected.Both patients and healthy control are all local Hui people.The DNA samples were extracted form esophageal cancer paraffin-embedded tissue blocks by using resin-based DNA extraction kits.And genotypes of CYPIA1,GSTT1 and GSTM1 were analyzed.Results Both esophageal cancer group and control group were investigated by age,gender,smoking history as well as alcohol consumption,and results showed that no significant difference between two groups(P0.05).MSP1 locus genotypes of the three genotypes in CYP1A1 in esophageal cancer group and control group were not significant distribution of difference(P0.05);GSTT1(-) genotype in esophageal cancer group and control group were significantly different(P0.05).GSTM1(-) genotype in the esophageal cancer group and control group were not significant differences in the distribution(P0.05).T1(-) M1(+),T1(+) M1(+) in the esophageal cancer group and control group were different in the distribution(P0.05).CYP1A1,GSTT1 and GSTM1 combined genotypes in esophageal cancer group and control group were not significant differences in the distribution.However,T1(-) M1(-) tc / cc group showed that combined genes in esophageal cancer might increase tendency(OR=2.212).Conclusion The Msp1 CYP1A1 polymorphism alone may not relate with the recurrence of esophageal cancer in Ningxia Hui nationality.However,GSTT1(-) genotype maybe one of the risk factors of esophageal cancer.The deletion of GSTT1 and GSTM1 genotypes maybe related with esophageal cancer in Ningxia Hui nationality.