Effect Observation of Citalopram in Treatment of Post-stroke Depression and Anxiety

Objective To observe effect of Citalopram in treatment of post-stroke depression and anxiety.Methods A total of 200 patients with post-stroke depression and anxiety in our department during January 2010 and January 2012 were randomly divided into therapy group(n = 100) and control group(n = 100).Based on conventional therapy,the control group was given positive psychological intervention,while therapy group was given Citalopram treatment(20 mg oral,1 time/d) and positive psychological intervention.Scores and effects of Hamilton depression scale(HAMD) and Hamilton anxiety scale(HAMA) in the two groups before and after treatment were compared,and adverse reactions were observed.Results Scores of HAMD and HAMA at 1,2,4 and 6 weeks after treatment were significantly lower than those before treatment in two groups(P 0.01).Scores of HAMD and HAMA in therapy group were significantly lower than those in control group(P 0.01),total effective rate in therapy group was also higher than that in control group(P 0.01).There was no adverse reaction in two groups.Conclusion The method of Citalopram in treatment of post-stroke depression and anxiety is effective and safe,which can improve the patients' quality of life.