Effects of 80MeV ~(12)C~(+6)/u ion irradiation on bone marrow cell cycle distribution of mice

The heads of the BALB/c mice were irradiated with 0, 0.5, 1, 2, 4 or 10 Gy of 12 C 6+ ions (80MeV/ u) and then the cell cycle distribution was analyzed by flow cytometry. At 36 h after irradiation, the G1/G0 phase cells were arrested significantly (P0.05) with the increase of irradiated dose, while the G2/M phase cells were reduced markedly (P0.05). After whole head irradiation (WHI) with heavy ions, the bone marrow cell cycle distribution of mice had significant changes, which indicates that ionization radiation may have an indirect effect on the bone marrow cell cycle distribution.