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2002•China Preventive MedicineRequires access

Effect of X- irradiation on Mice Bone Marrow Cell Cycle

Shibo Fu

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Abstract

To investigate the effect of whole body X - irradiation with different doses on mice bone marrow cell cycle.Methods Cell cycle was analyzed by flow cytometry (FCM) following staining of cells with propidium iodide (PI) . Results It was found that G1 and G2 phases of bone marrow cells increased significantly at 12h after whole body irradiation (WBI) with the doses of 1.0, 2.0, 4.0 and 6.0 Gy, whereas S phase cells were decreased at the same times.However, S phase was increased significantly at 72h following 0.05, 0.075, 0.1 and 0.2 Gy low dose X- irradiation.Conclusion These results suggest that Gl and G2 arrest could be induced by X - irradiation with the doses above 0.5Gy.S phase could be stimulated by low dose X - rays below 0.2Gy.

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What this paper is about

To investigate the effect of whole body X - irradiation with different doses on mice bone marrow cell cycle.Methods Cell cycle was analyzed by flow cytometry (FCM) following staining of cells with propidium iodide (PI) . Results It was found that G1 and G2 phases of bone marrow cells increased significantly at 12h after whole body irradiation (WBI) with the doses of 1.0, 2.0, 4.0 and 6.0 Gy, whereas S phase cells were decreased at the same times.However, S phase was increased significantly at 72h following 0.05, 0.075, 0.1 and 0.2 Gy low dose X- irradiation.Conclusion These results suggest that Gl and G2 arrest could be induced by X - irradiation with the doses above 0.5Gy.S phase could be stimulated by low dose X - rays below 0.2Gy.

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Available abstract

To investigate the effect of whole body X - irradiation with different doses on mice bone marrow cell cycle.Methods Cell cycle was analyzed by flow cytometry (FCM) following staining of cells with propidium iodide (PI) . Results It was found that G1 and G2 phases of bone marrow cells increased significantly at 12h after whole body irradiation (WBI) with the doses of 1.0, 2.0, 4.0 and 6.0 Gy, whereas S phase cells were decreased at the same times.However, S phase was increased significantly at 72h following 0.05, 0.075, 0.1 and 0.2 Gy low dose X- irradiation.Conclusion These results suggest that Gl and G2 arrest could be induced by X - irradiation with the doses above 0.5Gy.S phase could be stimulated by low dose X - rays below 0.2Gy.

Key concepts: Propidium iodide, Bone marrow, Cell cycle, Irradiation, Flow cytometry, Nuclear medicine, Cell, Chemistry

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