Experimental Study on Adaptive Response of Bone Marrow Cells Induced by Low-dose ~(12)C~(+6) Ion Beam Radiation in Mice

Objective To study the characteristics of hematopoietic system adaptive response of low-dose heavy ion 12C+6 radiation in mice.Methods The mice were irradiated high-dose(2.0 Gy) 12C+6 in advance of a low-dose(0.050,0.075 Gy) 12C+6 ion beam total body irradiation,in which a group of mice were killed 24 h and indicators of peripheral blood were measured,organ coefficient,bone marrow cells micronucleus,bone marrow DNA content;mice received one-time 2.0 Gy whole body irradiation,the 30 d survivals were observed.Results Compared with high-dose radiation directly,0.050 Gy low-dose irradiated mice were significantly higher peripheral WBC,bone marrow DNA content increased,mice bone marrow cells micronucleus rate decreased(P 0.05 ~ 0.01),the other indexes showed no significant difference.0.075 Gy low-dose irradiated mice peripheral blood leukocytes were lower compared with control group,the other index showed no significant difference.Conclusion The low-dose total body irradiation of carbon ion beam irradiation dose antagonized attack reduces the WBC number,bone marrow cells after irradiation reduces the micronucleus rate and bone marrow DNA content significantly increases the average survival time of irradiated mice.The adaptive response of mice bone marrow hematopoietic cells induces excitatory effect in the hematopoietic tissue which has important reference value for cancer radiological therapy and radiological protection of heavy ion beams.