Clinical analysis of misoprostol for prevention of postpartum hemorrhage

Objective: To investigate the clinical effects of misoprostol for preventing postpartum hemorrhage.Methods:In this study,A total of 400 puerpera scheduled for vaginal delivery in the Department of Obstetrics of our hospital during July 2009 and December 2010 were enrolled and randomly divided into 3 groups.Treatments were all given immediately after the fetus was delivered.For the misoprostol group,oral administration of 400μg misoprostol;for oxytocin + misoprostol group,oral administration of 400μg misoprostol + intravenous drip of 20U oxytocin was given,while the oxytocin group was only given intravenous drip of 20U oxytocin.Average amount of bleeding 2 h post-partum of the three groups were observed and compared.Results:Average amount of bleeding 2 h post-partum of the three groups were listed as following: misoprostol group,(280±46)mL;oxytocin + misoprostol group,(216±45)mL;oxytocin group,(360±49)mL;indicating significant better prevention effects in oxytocin + misoprostol group comparing with that in other two groups.Oxytocin group showed the highest incidence of post-partum bleeding(P0.01).Conclusions:Misoprostol can promote stronger uterine contractions than oxytocin,thus has good prevention effects for post-partum bleeding.