2009•Wuhan Daxue xuebao. Yixue banRequires access
Liver Aquaporin 8 Expression in Rats During Biliary Obstruction and Biliary Decompression
Wei Liu
Open publisher page 1 citations
Abstract
Objective: To investigate the change of liver aquaporin 8(AQP8) expression and its clinical significance during biliary obstruction and biliary decompression.Methods: Forty rats were divided into four groups randomly as control group,one week of bile duct ligation(BDL-1W) group,two weeks of bile duct ligation(BDL-2W) group,and biliary decompression(BDL-D) group.Immunohistochemistry was used to evaluate the expression of AQP8 in liver.Results: AQP8 immunoreactive products were observed on the membrane and inside of hepatocytes,especially in control group.IHC showed that the expression of AQP8 in the hepatocytes was decreased in both BDL groups when compared to the control group(P0.05),and AQP8 expression of BDL-2W group was lower than that in BDL-1W group.However,AQP8 expression was increased in BDL-D group compared to that of BDL-2W group(P0.05).Conclusion: The expression of AQP8 in the hepatocytes is decreasing as the result of bile duct ligation untill the ligation is removed,which indicates that there is a relationship between AQP8 expression and bile secretion.