Changes of common bile duct diameter and pressure and liver function in dogs with obstructive jaundice

Objective: To detect the diameter and pressure of common bile duct and the liver function in obstructive jaundice dogs. Methods: Biliary obstruction animal models were established on dogs by ligating common bile duct. Thirty dogs with obstructive jaundice through bile duct ligation (BDL)were randomly divided into 5 groups: control, BDL5, BDL10, BDL15, BDL20 group. The common bile duct diameter and pressure were measured. And the liver function indicators which include serum total bilirubin(TBIL), direct bilirubin(DBIL), alanine transferase(ALT), aspartate aminotransferase(AST)and alkaline phosphatase(ALP)were measured. Results: With the extension of ligating time, the common bile duct pressure reached the highest level after 5 days. The bile duct diameter continued to expanse during the obstruction period, and the level of BDL20 were about 10 times higher than those of the control group. The ALP、TBIL、DBIL、ALT and AST levels in serum increased to the peak rapidly, and then the levels stabilized and decreased, but were still higher than that of the control group(P0.01). Conclusion: Obstructive jaundice can lead to a rapid pressure increase and continuous expansion of common bile duct, and can influence the liver function.