Effects of Inhaled Oral Montelukast Combined with Budesonide/Formoterol in Treatment of Patients with Chronic Asthmatic Bronchitis

Objective:To investigate the efficacy of inhaled oral montelukast(singulair) combined with budesonide/formoterol(symbicort) in treatment of patients with chronic asthmatic bronchitis.Methods:68 cases with chronica sthmatic bronchitis were randomly divided into two groups,in the control group was given conventional anti-inflammatory,antispasmodic,expectorant and budesonide/formoterol(symbicort)inhalation treatment,the case of treatment group were treated based on the control group treatment and additional oral montelukast(singulair) 10 mg every night before bed time;course of 14 days.After the treatment,evaluation of clinical efficacy in 2 groups respectively,and tested the lung function's FEV1%,FVC,PEF before and after treatment in 14th day,compared them,and recorded the hospital readmission rate for one year.Results:the total effective of treatment group(91.18%),and the total efficiency of control group(76.47%),there was statistically significant difference(P0.05);treatment group lung function FEV1%,FVC,PEF improved significantly better than the control group.One year readmission rate of treatment group was significantly less than control group.Conclusion:Montelukast combined with budesonide/formoterol,is significantly better than budesonide,formoterol(symbicort) for chronic asthmatic bronchitis,it should be promoted.