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2009•Di-Si Junyi Daxue xuebaoRequires access

Treatment efficacy of amiodarone and cedilanid on paroxysmal atrial fibrillation

Hu Jin

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Abstract

AIM: To compare the efficacy and safety of amiodarone and cedilanid on the treatment of paroxysmal atrial fibrillation.METHODS: One hundred and fourteen patients with paroxysmal atrial fibrillation caused by various cardiovascular diseases were randomly divided into amiodarone group(60 cases) and cedilanid group(54cases).The cases in amiodarone group received intravenous injection of 150 mg amiodarone in 10 min and then followed by intravenous drip infusion 1 mg/min.The cases in cedilanid group received intravenous injection of 0.4 mg.Doses were regulated by therapeutic efficacy.Blood pressure,ventricular rate and reversion were observed.RESULTS: The total efficiency rate of amiodarone group was 88.3%,higher than that of cedilanid group(72.2%,P0.05).The mean ventricular rate decreased by 39.0% and 28.0% in the two groups respectively.The mean reversion time of the two groups was(56.4±26.6) and(79.9±35.4) minutes respectively(P0.05).Only mild side effects were observed in the two groups.CONCLUSION: Both amiodarone and cedilanid are safe and have only mild side effects but intravenous transfusion of amiodarone is more effective than cedilanid in the treatment of paroxysmal atrial fibrillation.

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AIM: To compare the efficacy and safety of amiodarone and cedilanid on the treatment of paroxysmal atrial fibrillation.METHODS: One hundred and fourteen patients with paroxysmal atrial fibrillation caused by various cardiovascular diseases were randomly divided into amiodarone group(60 cases) and cedilanid group(54cases).The cases in amiodarone group received intravenous injection of 150 mg amiodarone in 10 min and then followed by intravenous drip infusion 1 mg/min.The cases in cedilanid group received intravenous injection of 0.4 mg.Doses were regulated by therapeutic efficacy.Blood pressure,ventricular rate and reversion were observed.RESULTS: The total efficiency rate of amiodarone group was 88.3%,higher than that of cedilanid group(72.2%,P0.05).The mean ventricular rate decreased by 39.0% and 28.0% in the two groups respectively.The mean reversion time of the two groups was(56.4±26.6) and(79.9±35.4) minutes respectively(P0.05).Only mild side effects were observed in the two groups.CONCLUSION: Both amiodarone and cedilanid are safe and have only mild side effects but intravenous transfusion of amiodarone is more effective than cedilanid in the treatment of paroxysmal atrial fibrillation.

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Available abstract

AIM: To compare the efficacy and safety of amiodarone and cedilanid on the treatment of paroxysmal atrial fibrillation.METHODS: One hundred and fourteen patients with paroxysmal atrial fibrillation caused by various cardiovascular diseases were randomly divided into amiodarone group(60 cases) and cedilanid group(54cases).The cases in amiodarone group received intravenous injection of 150 mg amiodarone in 10 min and then followed by intravenous drip infusion 1 mg/min.The cases in cedilanid group received intravenous injection of 0.4 mg.Doses were regulated by therapeutic efficacy.Blood pressure,ventricular rate and reversion were observed.RESULTS: The total efficiency rate of amiodarone group was 88.3%,higher than that of cedilanid group(72.2%,P0.05).The mean ventricular rate decreased by 39.0% and 28.0% in the two groups respectively.The mean reversion time of the two groups was(56.4±26.6) and(79.9±35.4) minutes respectively(P0.05).Only mild side effects were observed in the two groups.CONCLUSION: Both amiodarone and cedilanid are safe and have only mild side effects but intravenous transfusion of amiodarone is more effective than cedilanid in the treatment of paroxysmal atrial fibrillation.

Key concepts: Amiodarone, Medicine, Atrial fibrillation, Ventricular rate, Paroxysmal atrial fibrillation, Cardiology, Reversion, Internal medicine

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Treatment efficacy of amiodarone and cedilanid on paroxysmal atrial fibrillation — Research Paper | ScholarLens