Expression of amplified in breast cancer 1 and nuclear transcription factor kappa B in gastric carcinomas

Objective To investigate the expression of amplified in breast cancer 1( AIB1) and nuclear transcription factor kappa B( NF-κB) in gastric carcinoma and discuss their correlation in gastric carcinoma tissues inorder to provide the theory basis for the prevention and cure of gastric carcinoma with the AIB1 and NF-κB as target. Methods The expression of AIB1 and NF-κB in gastric carcinoma tissues of 88 cases and para-cancerous tissues of 85 cases were examined with immunohistochemical technique. The datum together with clinical pathologic characteristic were analyzed. Results The positive rates of AIB1 and NF-κB in carcinoma tissues were 75. 0% and 72. 7% respectively,which were significantly higher than those in para-cancerous tissues( 7. 1% and 11. 8%),and the differences were significant( P 0. 05). The expression of AIB1 in gastric carcinoma was associated with lymph node metastasis and clinical tumor staging( P 0. 05); the expression of NF-κB in gastric carcinoma was associated with lymph node metastasis and pathological grade( P 0. 05). AIB1 expression was positive correlated with NF-κB in gastric carcinoma( r = 0. 236,P 0. 05). Conclusions AIB1 and NF-κB play important roles in carcinogenesis,and are involved in the formation of gastric carcinoma. Besides,they are also associated with the invasion,metastasis and prognosis of gastric carcinoma.