Clinical results of treating metaphase and advanced hepatic carcinoma with intra-hepatic artery chemotherapy and embolizing therapy

Objective To study the clinical effect of treating metaphase and advanced primary massive hepatic carcinoma with intra-hepatic artery chemotherapy and embolizing therapy.Methods Retrospectively analyzed the data of 246 patients with primary massive liver carcinoma who were treated by intra-hepatic artery chemotherapy and embolizing therapy.These patients were randomly divided into two groups: one group(treatment group,126 cases) was embolized by iodinated oil(6-27 ml),ferrosoferric oxide(250 μm),mitomycin(10 mg) and 5 Fluorouracil(250 mg),and the stem of hepatic artery were embolized with gelatin sponge.The other one(control group,120 cases) was treated by iodinated oil(6-27 ml) and gelatin sponge only.Then compared the size of the tumor,the effective rate and the survival rate in near future between these two groups.Results The effective rate in near future of the treatment group is higher than that of the control group.The survival rate in 1, 2 and 3 years was 89.3%,42.7%,and 31.2% respectively in treatment group,and in the control group,the number was 53.8%,14.9%,and 12.6% respectively.Conclusion Compared with single embolizing therapy,combining the intra-hepatic artery chemotherapy with embolizing therapy can increase the effective rate and survival rate in near future significantly.This method is effective in treating the metaphase and advanced primary massive liver carcinoma.