Clinical observation on efficacy of pirarubicin combined with chemoembolization in the intrahepatic artery transcatheter chemotherapy of middle-late stage hepatic carcinoma

Objective To investigate the clinical efficacy and methods of intrahepatic artery chemoemboli-zation with ultra fluid lipoid combined with anticarcinoma drugs in treatment of middle-late stage hepatic carcinoma which can not be operated and treated with intravenous chemotherapy. Methods Supper-selective hepatic artery Seldinger catheterization via formal artery was performed in 96 cases. Single dose was mitomycin(MMC) 10 mg,cis-platin(CDDP) 60 mg,pirarubicin(THP) 60 mg, 5-Fu 1 500 mg and ultra fluid lipoid made in France 10-20 mg. Results In the group of 82 patients with primary hepatic carcinoma, the level of AFP increased to different degrees. Ranging from 626ng/ml to 2 565 ng/ml before treatment. After treatment the level of AFP declined obviously, usually to below 35 ng/ml and reaching the normal level. In the group of metastatic hepatic carcinoma, the level of AFP heightened slightly before treatment, and the symptoms possibly improved obviously after treatment. Examined with CT scan and DSA arteriography during the operation, the focus was found reduced in size. Of the 82 primary hepatic carcinoma patients, 6 were cured.The quality of life of 96 patients improved and their life span was prolonged . Conclusion Hepatic artery embolization with lipoidal emulsion combined with anticarcinoma drug for treatment of Child grades B and C hepatic carcinoma patients, which can be accepted by most patients, can not only control the development of the tumor, but also reduce its size.