2010•Hebei Journal of Traditional Chinese MedicineRequires access
Experimental study of WeidongfangIon gastric motility of rat with functional dyspepsia
Jiang Guo-rong
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Abstract
Objective To study the effects of WeidongfangⅠ on the gastrointestinal motility.Methods 60 rats were randomly control group,model group,Cisapride group,low-dose Weidongfang,middle-dose Weidongfang and high-dose Weidongfang groups.The animal model of gastrointestinal motility disorder in rats was established by licorice root decoction(LRD).Intragastric administration of distilled water(10 mL/kg),Cisapride(1.4 mg/kg),and low,middle-and high-dose Weidongfang(1.2 g/kg,3.6 g/kg and 10.8 g/kg)were carried on each group,respectively.Gastric emptying rate,intestinal propulsive rate,MTL,Gas and VIP in blood of rats were measured for effect of evaluation.Results There were significant differences between Weidongfang groups,model group and group on gastric emptying rate,intestinal propulsive rate,MTL,Gas and VIP in blood.Gastric emptying rate,intestinal propulsive rate,MTL and Gas were increased,and VIP was decreased in middle-dose Weidongfang and high-dose Weidongfang groups.Conclusion WeidongfangⅠimprove motility function of intestinal of animal model by increasing the content of MTL,Gas,and decreasing that of VIP in blood of the models.