Effect of Xuanfu Daizhe Decoction on Motilin,Gastrin and Vasoactive Intestinal Peptide in Blood and Tissuein Rats with Low Gastric Motility

Objective:To observe the effect for Xuanfu Daizhe Decoction(XFDZD) on motilin(MTL),gastrin(GAS) and vasoactive intestinal peptide(VIP) content in blood and tissue in rats with low gastric motility.Method:Seventy Wistar rats were divided into normal group(10 rats) and model group(60 rats) at random.Each rat of model group was irritated stomach with liquorice decoction(10 g·kg-1).After stomach irritation,model group were divided into model group of 3 days,model group of 7 days,low,medium,high dosage groups of XFDZD,and the group of domperidone.The stomach with low gastric motility was irritated with domperidone,and the treatment groups were treated with XFDZD at different doses.Then the content of MTL,GAS,VIP in blood and gastric antrum was tested with radioimmunopercipitation.Result:Liquorice decoction could make rat model of low gastric motility.XFDZD could make MTL,GAS content increase in rat's blood and organization,at the same time make VIP content reduce,campared with model groups,there were all significance difference(P0.05 or P0.01).Conclusion:XFDZD could treat disease of gastrointestinal dismotility by regulating brain-gut peptides content in rat's blood or gastric antrum.