Expressions and significance of HER-2 and GST-π in human gastric carcinoma

Objective:To investigate the expressions of HER-2 and GST-πin human gastric carcinoma and to study the relationship with the clinicopathologic factors of gastric carcinoma.Methods: The Envision immunohistochemical stain method was used to detect HER-2 and GST-πprotein expressions in 70 sample of gastric carcinoma tissues.And their corresponding clinical data were analyzed retrospectively.Results: The positive expression rates of them were 27.1%(19/70) and 58.6%(41/70).The positive expression rates were closely related to the differentiation of the cancer,invasion depth,lymphatic metastasis and TNM(P0.01,P0.05),but not to the patient' s sex,age,tumor site and size(P0.05).There was a positive correlation between HER-2 and GST-π expressions in gastric cancer tissues.Conclusion: HER-2 and GST-π expressions participate in the development,invasion and metastasis process of gastric cancer.Combined detection of them can be looked as an important symbol for guiding the molecular targeting therapy and chemotherapy of gastric cancer,and judging the prognosis of gastric cancer.