Observing the effect of montelukast on 98 children with cough variant asthma

Objective:To study curative effect of Montelukast in children with cough variant asthma(CVA).Methods:98 children with CVA were assigned to two groups in the ratio of 2∶1.65 cases were in the study-group and the others belonging to the control group.The control group was treated with-Terbutaline and Ketotifen.The treatment withdraw until the symptom disappeared,the recurrence rate of CVA was investigated at the follow-up of 12 months.The study group was treated with Montelukast besides Terbutaline and Ketotifen were with drawn until the symptom disappeared,however,Montelukast was still taken till the course of treatment reached 12 weeks.The incidence of CVA recurrence rate was also investigated at the follow-up of 12 months.For 32 children who were 2~12 year old,the FEV 1 and PEF were measured before treatment and 12 weeks after treatment.Results:The remission time of study group was shorter than the control group;the recurrence rate and incidence of CVA-Asthma convention were lower.Lung function in study group improved significantly compared to the control group after 12 weeks-treatment(P0.01).Conclusion:The curative effect of Montelukast in children with CVA is significant,with little side effect and good obedience.