ScholarLens Back to search
2006•Shanghai yixueRequires access

Relevance of serum and urinary transforming growth factor-β_1 and urinary type IV collagen with early diabetic nephropathy in type 2 diabetic patients

Zhuang Liyin

Open publisher page 0 citations

Abstract

Objective To appraise the relevance of serum and urinary transforming growth factor(TGF)-β_1 and urinary type Ⅳ collagen(Ⅳ-C) with early diabetic nephropathy in type-2 diabetic patients. Methods 149 cases of type-2 diabetes were divided into normoalbuminuria group and microalbuminuria group,according to the following items: urine albumin excretion rate(UAER).UAER,TGF-β_1,Ⅳ-C,blood TGF-β_1,blood glucose,blood lipid,C-peptide,blood creatinine(Cr),urea nitrogen(BUN),glycosylated hemoglobin(HbA_1c),were mea-(sured.) Results 24 h urinary TGF-β_1,Ⅳ-C and serum TGF-β_1 in the microalbuminuria group were markedly higher than those in normoalbuminuria group(P0.01),24 h urinary TGF-β_1,Ⅳ-C and serum TGF-β_1 were also positively correlated with UAER(P0.01). Conclusions 24 h urinary TGF-β_1,Ⅳ-C and serum TGF-β_1 seem to be the early markers of diabetic nephropathy.

About this research paper

What this paper is about

Objective To appraise the relevance of serum and urinary transforming growth factor(TGF)-β_1 and urinary type Ⅳ collagen(Ⅳ-C) with early diabetic nephropathy in type-2 diabetic patients. Methods 149 cases of type-2 diabetes were divided into normoalbuminuria group and microalbuminuria group,according to the following items: urine albumin excretion rate(UAER).UAER,TGF-β_1,Ⅳ-C,blood TGF-β_1,blood glucose,blood lipid,C-peptide,blood creatinine(Cr),urea nitrogen(BUN),glycosylated hemoglobin(HbA_1c),were mea-(sured.) Results 24 h urinary TGF-β_1,Ⅳ-C and serum TGF-β_1 in the microalbuminuria group were markedly higher than those in normoalbuminuria group(P0.01),24 h urinary TGF-β_1,Ⅳ-C and serum TGF-β_1 were also positively correlated with UAER(P0.01). Conclusions 24 h urinary TGF-β_1,Ⅳ-C and serum TGF-β_1 seem to be the early markers of diabetic nephropathy.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To appraise the relevance of serum and urinary transforming growth factor(TGF)-β_1 and urinary type Ⅳ collagen(Ⅳ-C) with early diabetic nephropathy in type-2 diabetic patients. Methods 149 cases of type-2 diabetes were divided into normoalbuminuria group and microalbuminuria group,according to the following items: urine albumin excretion rate(UAER).UAER,TGF-β_1,Ⅳ-C,blood TGF-β_1,blood glucose,blood lipid,C-peptide,blood creatinine(Cr),urea nitrogen(BUN),glycosylated hemoglobin(HbA_1c),were mea-(sured.) Results 24 h urinary TGF-β_1,Ⅳ-C and serum TGF-β_1 in the microalbuminuria group were markedly higher than those in normoalbuminuria group(P0.01),24 h urinary TGF-β_1,Ⅳ-C and serum TGF-β_1 were also positively correlated with UAER(P0.01). Conclusions 24 h urinary TGF-β_1,Ⅳ-C and serum TGF-β_1 seem to be the early markers of diabetic nephropathy.

Key concepts: Diabetic nephropathy, Microalbuminuria, Medicine, Internal medicine, Endocrinology, Creatinine, Urinary system, Blood urea nitrogen

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Relevance of serum and urinary transforming growth factor-β_1 and urinary type IV collagen with early diabetic nephropathy in type 2 diabetic patients — Research Paper | ScholarLens