The Change of Serum TGF-β_1 and its Clinical Significance in Type 2 Diabetics Nephropathy

Objective:To test the change of serum transforming growth factor beta-β1(TGF-β1) and investigate its clinical significance in type 2 diabetic nephropathy(DN).Methods:67 cases of patients with type 2 diabetes accord ing to their urinary albumin excretion rate(UAER) were divided into three groups: normal albuminuria group,microalbuminuria group and clinical proteinuria.Serum TGF-β1 levels were detected with enzyme-linked immunosersorbent assay in 67 patients with type 2 diabetes and 20 normal controls.Results:①Serum TGF-β1 levels significantly increased in diabetic patients compared with that in normal controls(P0.05).② Serum TGF-β1 in microalbuminuria group was significantly higher than that of normal albuminuria group(P0.05).Compared with microalbuminuria group,Serum TGF-β1 was significantly higher in clinical proteinuria group(P0.05).③Serum TGF-β1 levels was highly correlated with UAER(r=0.674,P0.01).Conclusion:TGF-β1 was probably involved in the process of pathophysiology in type 2 diabetic nephropathy.Serum TGF-β1 was significantly increased in normal albuminuria group and it might be an early marker for predicting diabetic nephropathy and assessing its severity.