Effectiveness analysis of short-course moxifloxacin treatment in acute exacerbation of chronic obstructive pulmonary disease

Objective To compare the effectiveness of moxifloxacin short-course therapy with standard-course therapy in acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods Outpatients with COPD during acute exacerbation in a stable condition were enrolled and randomized into moxifloxacin short-course group(n=43,400 mg qd for 5 days) and standard-course group(n=43,400 mg qd for 10 days).All patients were visited for 6 months after the therapy.We observed and compared the efficacy parameters including dinical efficacy,bacterial eradication rate,forced expiratory volume in one second(FEV1) and the frequency of exacerbation in the next 6 months.Results Clinical efficacy,bacterial eradication rate FEV1 and the frequency of exacerbation in the next 6 months were similar for the two groups(P0.05).Conclusions Short-course treatment of moxifloxacin taken orally is effective in the therapy of AECOPD.