Impacts of Qianliexianyan No. 1 on the Contents of Serum IL-2 and IL-6 in CNP Rats

Objective To explore the effect mechanism of Qianliexianyan No. 1 in the treatment of chronic nonbacterial prostatitis( CNP). Methods Seventy rats were randomized into a blank group,a model group,a positive group,a small-dose Qianliexianyan No. 1 group( small-dose group),a median-dose group and a large-dose group. In the blank group,the physiological saline 1ml was applied for subcutaneous injection. The mixture emulsion of the purification solution of prostate protein and Freund's complete adjuvant( FAC),1ml was applied for multi-subcutaneous injection in the rest groups for modeling. The modeling was repeated once again in 30 days. The medication via gastric infusion was given in 45 days. After continuous medication for 4 weeks,the prostate tissue was separated for the calculation of prostate index. The serum was collected for the content detection of IL-2 and IL-6. Results Compared with the model group,the contents of IL-2 and IL-6 were all reduced in the rats of the rest groups,indicating the statistically significant difference( P 0. 05). Compared with the positive group,the contents of IL-2 and IL-6 were higher in the small-dose group,indicating the statistically significant difference( P 0. 05). Compared with the small-dose group,thecontents of IL-2 and IL-6 were much lower in the media-dose and large-dose groups,indicating the statistically significant difference( P 0. 05). Conclusion Qianliexianyan No. 1 at the median and large dose effectively reduces the expressions of serum IL-2 and IL-6 in CNP rat models. It improves the local immune function and inhibits the inflammatory reaction.