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2005•Chinese Journal of Laboratory DiagnosisRequires access

The clinical significance of PTEN protein expression in colorectal carcinoma

Guang Zhang

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Abstract

Objective To investigate the correlation between the expression of tumour suppressor gene PTEN and clinicalpathological features in colorectal carcinoma. Methods The expression of PTEN protein in normal colorectal mucosa and colorectal carcinoma was observed by S P immunohistochemical assay. Results The positive expression rate of PTEN protein was 25 00%(15/60). PTEN protein expression was positively correlated with pathological differentiational degree( r =0 869, P 0 05), negatively with TNM staging, lymph nodes metastasis and hepatic metastasis( r =-0 791, r =-0 741, r =-0 634, P 0 05). Conclusion PTEN played a pivotal role in progression of colorectal carcinoma. The expression of PTEN is closely related to clinicopathological features in colorectal carcinoma, and could be used as marker of tumour burden of colorectal carcinoma.

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Objective To investigate the correlation between the expression of tumour suppressor gene PTEN and clinicalpathological features in colorectal carcinoma. Methods The expression of PTEN protein in normal colorectal mucosa and colorectal carcinoma was observed by S P immunohistochemical assay. Results The positive expression rate of PTEN protein was 25 00%(15/60). PTEN protein expression was positively correlated with pathological differentiational degree( r =0 869, P 0 05), negatively with TNM staging, lymph nodes metastasis and hepatic metastasis( r =-0 791, r =-0 741, r =-0 634, P 0 05). Conclusion PTEN played a pivotal role in progression of colorectal carcinoma. The expression of PTEN is closely related to clinicopathological features in colorectal carcinoma, and could be used as marker of tumour burden of colorectal carcinoma.

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Available abstract

Objective To investigate the correlation between the expression of tumour suppressor gene PTEN and clinicalpathological features in colorectal carcinoma. Methods The expression of PTEN protein in normal colorectal mucosa and colorectal carcinoma was observed by S P immunohistochemical assay. Results The positive expression rate of PTEN protein was 25 00%(15/60). PTEN protein expression was positively correlated with pathological differentiational degree( r =0 869, P 0 05), negatively with TNM staging, lymph nodes metastasis and hepatic metastasis( r =-0 791, r =-0 741, r =-0 634, P 0 05). Conclusion PTEN played a pivotal role in progression of colorectal carcinoma. The expression of PTEN is closely related to clinicopathological features in colorectal carcinoma, and could be used as marker of tumour burden of colorectal carcinoma.

Key concepts: PTEN, Immunohistochemistry, Colorectal cancer, Cancer research, Medicine, Pathological, Metastasis, Carcinoma

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