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2002•Pharmaceutical Journal of Chinese People's Liberation ArmyRequires access

The effect of Radix Axtragali injection on levels of superoxide dismutase and nitric oxide in rat brain after sleep deprivation

Xing Wu

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Abstract

Aim To observe the content of nitric oxide (NO) and the activity of superoxide dismutase (SOD) in rat brain and behavior Changes after total sleep deprivation (TSD) and to explore the effect of Radix Axtragali on TSD.Methods NO levels and SOD activity in the front cortex and hippocampus of Sprague-Dawley rats were assayed after TSD for 3d induced by flower pot technique.Results NO levels and SOD activity in the front cortex and hippocampus after TSD were increased compared with those of the control cage groups (CC)(P0.01) and significantly decreased compared with those of the groups of Radix Axtragali(P0.01～0.05).There were great behavior changes after TSD and the Radix Axtragali could relieve those changes.Conclusion The results indicate that NO and Oxygen free radical may participated in the brain damage mechanisms during sleep deprivation and Radix Axtragali can reduce the effect.

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What this paper is about

Aim To observe the content of nitric oxide (NO) and the activity of superoxide dismutase (SOD) in rat brain and behavior Changes after total sleep deprivation (TSD) and to explore the effect of Radix Axtragali on TSD.Methods NO levels and SOD activity in the front cortex and hippocampus of Sprague-Dawley rats were assayed after TSD for 3d induced by flower pot technique.Results NO levels and SOD activity in the front cortex and hippocampus after TSD were increased compared with those of the control cage groups (CC)(P0.01) and significantly decreased compared with those of the groups of Radix Axtragali(P0.01～0.05).There were great behavior changes after TSD and the Radix Axtragali could relieve those changes.Conclusion The results indicate that NO and Oxygen free radical may participated in the brain damage mechanisms during sleep deprivation and Radix Axtragali can reduce the effect.

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Available abstract

Aim To observe the content of nitric oxide (NO) and the activity of superoxide dismutase (SOD) in rat brain and behavior Changes after total sleep deprivation (TSD) and to explore the effect of Radix Axtragali on TSD.Methods NO levels and SOD activity in the front cortex and hippocampus of Sprague-Dawley rats were assayed after TSD for 3d induced by flower pot technique.Results NO levels and SOD activity in the front cortex and hippocampus after TSD were increased compared with those of the control cage groups (CC)(P0.01) and significantly decreased compared with those of the groups of Radix Axtragali(P0.01～0.05).There were great behavior changes after TSD and the Radix Axtragali could relieve those changes.Conclusion The results indicate that NO and Oxygen free radical may participated in the brain damage mechanisms during sleep deprivation and Radix Axtragali can reduce the effect.

Key concepts: Sleep deprivation, Nitric oxide, Superoxide dismutase, Hippocampus, Radix (gastropod), Privation, Endocrinology, Internal medicine

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The effect of Radix Axtragali injection on levels of superoxide dismutase and nitric oxide in rat brain after sleep deprivation — Research Paper | ScholarLens