2003•Medical Journal of National Defending Forces in Northwest ChinaRequires access

Changes and significance of nitric oxide and superoxide dismutase in limbic system of the rats under acute stress

Hu Shu

Abstract

Objective:To observe the changes of nitric oxide (NO) and superoxide dismutase(SOD) in the rats under acute stress,and study the effects of NO and SOD on stress disorder.Methods:Acute stress model was established by forced swimming, the level of NO and the activity of SOD were measured in hippocampus,prefrontal,hypothalamus and midbrain.Results:The level of NO in hippocampus and hypothalamus in stress group was significantly higher than that of control group ( P 0.05),SOD activity in hippocampus,prefrontal,hypothalamus and midbrain in stress group was significantly higher than that of control group( P 0.05).Conclusion:NO and SOD may have effect on stress disorder.

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Key concepts: Hippocampus, Superoxide dismutase, Nitric oxide, Hypothalamus, Internal medicine, Endocrinology, Midbrain, Medicine