2002•Zhongguo linchuang xinlixue zazhiRequires access

The Effects of Sleep Deprivation on Brain Levels of Nitric Oxide Synthase and Nitric Oxide in Rat

Wamg Xiao-feng

Abstract

Objective: To explore the brain levels of nitric oxide (NO) and nitric oxide synthase(NOS) in rats after sleep deprivation. Methods: NO levels and NOS activity were assayed in different brain regions of Sprague-Dawley rats after sleep deprivation by flower pot compare with normal group (CC) and tank control groups (TC). Results: NO levels and NOS activity were increased in front cortex and hippocampus after SD compared with CC and TC (P0.01～0.05). Conclusion: The NO levels and activity of NOS are increased after sleep deprivation, NOS/NO may play an important role in learning and memory and modulating sleep

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Key concepts: Sleep deprivation, Nitric oxide, Nitric oxide synthase, Hippocampus, Psychology, Endocrinology, Internal medicine, Sleep (system call)