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A Clinicopathologic and Immunohistochemical Analysis of 45 Cases with Gastrointsetinal Stromal Tumors

Mao Zhiyuan

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Abstract

Objective: To investigate immunohistochemical characteristics of gastrointsetinal stromal tumors(GIST). Methods: In the study of 45 cases of GIST,clinico-pathologic characteristics were observed,all the cases were detected with immunohistochemical expressions of CD117,CD34,SMA and S-100 protein. Results: Of 45 cases,10 were benign,15 were bordline and 20 were malignant. The neoplastic cells were spindle,epitheliold or both in different proportion. As to immunohistochemical phenotype,the positive rates of CD117 and CD34 were 91.1% and 80%.Conclusions:GIST is the most frequent mesenchymal tumor in the gastrointsetinal tract with special morphologic and immunohistochemical characteristics,CD117 and CD34 are helpful to diagnosis.

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What this paper is about

Objective: To investigate immunohistochemical characteristics of gastrointsetinal stromal tumors(GIST). Methods: In the study of 45 cases of GIST,clinico-pathologic characteristics were observed,all the cases were detected with immunohistochemical expressions of CD117,CD34,SMA and S-100 protein. Results: Of 45 cases,10 were benign,15 were bordline and 20 were malignant. The neoplastic cells were spindle,epitheliold or both in different proportion. As to immunohistochemical phenotype,the positive rates of CD117 and CD34 were 91.1% and 80%.Conclusions:GIST is the most frequent mesenchymal tumor in the gastrointsetinal tract with special morphologic and immunohistochemical characteristics,CD117 and CD34 are helpful to diagnosis.

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Available abstract

Objective: To investigate immunohistochemical characteristics of gastrointsetinal stromal tumors(GIST). Methods: In the study of 45 cases of GIST,clinico-pathologic characteristics were observed,all the cases were detected with immunohistochemical expressions of CD117,CD34,SMA and S-100 protein. Results: Of 45 cases,10 were benign,15 were bordline and 20 were malignant. The neoplastic cells were spindle,epitheliold or both in different proportion. As to immunohistochemical phenotype,the positive rates of CD117 and CD34 were 91.1% and 80%.Conclusions:GIST is the most frequent mesenchymal tumor in the gastrointsetinal tract with special morphologic and immunohistochemical characteristics,CD117 and CD34 are helpful to diagnosis.

Key concepts: CD117, Immunohistochemistry, CD34, GiST, Medicine, Pathology, Stromal cell, Mesenchymal stem cell

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