Research on Correlation between IL-1β-511 Gene Polymorphism and Coronary Artery Heart Disease

Objective To explore the correlation between IL-1β-511 gene polymorphism and coronary heart disease(CHD).Methods 160 patients with CHD were treated as CHD group,and subjected to detect nucleotide polymorphism of IL-1β-511 SNP by using polymerase chain reactions-restriction fragment length polymorphism(PCR-RFLP)techniques,and 160 healthy people were selected as the normal control group.Results The frequency of genotypes TC,TT,CC were 61.25%,23.75% and 15.00% respectively in CHD group,while 57.50%,14.38% and 28.13% in control group(P0.01).The frequencies of mutant alleles T in CHD group(54.38%)were higher than that in control group(43.13%)(P0.01).TT was a risk genotype for the development of CHD(OR=2.51).The levels of TC and LDL-C among patients with mutant alleles T were(6.10±0.87)mmol/L and 4.01 mmol/L,respectively,which were higher than those among C patients with mutant alleles C.Conclusion There is significant correlation between IL-1β-511 gene polymorphism and the development of CHD.TT may be a genotype of higher risk for the development of CHD.